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Anti-HDAC3 Polyclonal Antibody 2

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货号 TMAB-06932

Anti-HDAC3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 HDAC3。Anti-HDAC3 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-HDAC3 Polyclonal Antibody 2

Anti-HDAC3 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-06932

Anti-HDAC3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 HDAC3。Anti-HDAC3 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-HDAC3 Polyclonal Antibody 2 is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Pig,Cow,Horse)
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Widely expressed.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human HDAC3/HD3
抗原种属
Human
基因名称
HDAC3
基因ID
8841
蛋白名称
Histone deacetylase 3
Uniprot ID
O15379
功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
化学信息
分子量Theoretical: 47 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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