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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HCN2+HCN4 Polyclonal Antibody

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货号 TMAB-06915

Anti-HCN2+HCN4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HCN2+HCN4。Anti-HCN2+HCN4 Polyclonal Antibody 可用于 WB。

Anti-HCN2+HCN4 Polyclonal Antibody

Anti-HCN2+HCN4 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06915

Anti-HCN2+HCN4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HCN2+HCN4。Anti-HCN2+HCN4 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HCN2+HCN4 Polyclonal Antibody is a Rabbit antibody targeting HCN2+HCN4. Anti-HCN2+HCN4 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Pig,Cow,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Multi-pass membrane protein.
组织特异性Highly expressed throughout the brain. Detected at low levels in heart.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5).
抗原信息
免疫原
KLH conjugated synthetic peptide: human HCN2 + HCN4
抗原种属
Human
基因名称
HCN2
基因ID
610
蛋白名称
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Uniprot ID
Q9UL51
功能
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
化学信息
分子量Theoretical: 97+129 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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