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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-H3-K4-HMTase SETD7 Polyclonal Antibody

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货号 TMAB-06864

Anti-H3-K4-HMTase SETD7 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 H3-K4-HMTase SETD7。Anti-H3-K4-HMTase SETD7 Polyclonal Antibody 可用于 WB。

Anti-H3-K4-HMTase SETD7 Polyclonal Antibody

Anti-H3-K4-HMTase SETD7 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06864

Anti-H3-K4-HMTase SETD7 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 H3-K4-HMTase SETD7。Anti-H3-K4-HMTase SETD7 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-H3-K4-HMTase SETD7 Polyclonal Antibody is a Rabbit antibody targeting H3-K4-HMTase SETD7. Anti-H3-K4-HMTase SETD7 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome (Probable).
组织特异性Widely expressed. Expressed in pancreatic islets.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SETD7
抗原种属
Human
基因名称
SETD7
基因ID
80854
蛋白名称
Histone-lysine N-methyltransferase SETD7
Uniprot ID
Q8WTS6
功能
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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