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Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody

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货号 TMAB-06856

Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Guanylyl Cyclase alpha 1。Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody

Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06856

Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Guanylyl Cyclase alpha 1。Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Guanylyl Cyclase alpha 1. Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Guanylyl Cyclase alpha 1
抗原种属
Human
基因名称
GUCY1A1
基因ID
2982
蛋白名称
Guanylate cyclase soluble subunit alpha-1
Uniprot ID
Q02108
化学信息
分子量Theoretical: 77 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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