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Anti-GTF3C5 Polyclonal Antibody

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货号 TMAB-06846

Anti-GTF3C5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GTF3C5。Anti-GTF3C5 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-GTF3C5 Polyclonal Antibody

Anti-GTF3C5 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06846

Anti-GTF3C5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GTF3C5。Anti-GTF3C5 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-GTF3C5 Polyclonal Antibody is a Rabbit antibody targeting GTF3C5. Anti-GTF3C5 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GTF3C5
抗原种属
Human
基因名称
GTF3C5
基因ID
9328
蛋白名称
General transcription factor 3C polypeptide 5
Uniprot ID
Q5T7U2
功能
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
化学信息
分子量Theoretical: 59 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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