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Anti-GTF2H2/TFIIH p44 Polyclonal Antibody

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货号 TMAB-06842

Anti-GTF2H2/TFIIH p44 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 GTF2H2/TFIIH p44。Anti-GTF2H2/TFIIH p44 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-GTF2H2/TFIIH p44 Polyclonal Antibody

Anti-GTF2H2/TFIIH p44 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06842

Anti-GTF2H2/TFIIH p44 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 GTF2H2/TFIIH p44。Anti-GTF2H2/TFIIH p44 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍


生物活性
产品描述
Anti-GTF2H2/TFIIH p44 Polyclonal Antibody is a Rabbit antibody targeting GTF2H2/TFIIH p44. Anti-GTF2H2/TFIIH p44 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Widely expressed, with higher expression in skeletal muscle.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human GTF2H2
抗原种属
Human
基因名称
GTF2H2
基因ID
蛋白名称
General transcription factor IIH subunit 2
Uniprot ID
功能
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
化学信息
分子量Theoretical: 44 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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