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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GRM1+GRM5 Polyclonal Antibody

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货号 TMAB-06786

Anti-GRM1+GRM5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GRM1+GRM5。Anti-GRM1+GRM5 Polyclonal Antibody 可用于 WB。

Anti-GRM1+GRM5 Polyclonal Antibody

Anti-GRM1+GRM5 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06786

Anti-GRM1+GRM5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GRM1+GRM5。Anti-GRM1+GRM5 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-GRM1+GRM5 Polyclonal Antibody is a Rabbit antibody targeting GRM1+GRM5. Anti-GRM1+GRM5 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
抗原信息
免疫原
KLH conjugated synthetic peptide: human MGLUR1 + MGLUR5
抗原种属
Human
基因名称
GRM1
基因ID
2911
蛋白名称
Metabotropic glutamate receptor 1
Uniprot ID
Q13255
功能
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
化学信息
分子量Theoretical: 130 kDa. Actual: 140-150 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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