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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GRB 14 Polyclonal Antibody

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货号 TMAB-06761

Anti-GRB 14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GRB 14。Anti-GRB 14 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-GRB 14 Polyclonal Antibody

Anti-GRB 14 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06761

Anti-GRB 14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GRB 14。Anti-GRB 14 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-GRB 14 Polyclonal Antibody is a Rabbit antibody targeting GRB 14. Anti-GRB 14 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, Golgi apparatus membrane, Peripheral membrane protein, Endosome membrane.
组织特异性Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phospho-tyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. An additional member of the GRB7 family, designated GRB14, contains a Pleckstrin homology domain in its central region and a carboxy-terminal SH2 domain. GRB14 mRNA is expressed at high levels in a broad range of tissues including liver, kidney, pancreas, testis, ovary, heart and skeletal muscle. Expression of the GRB14 protein in breast carcinomas is strongly correlated with estrogen receptor positivity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GRB 14
抗原种属
Human
基因名称
GRB14
基因ID
2888
蛋白名称
Growth factor receptor-bound protein 14
Uniprot ID
Q14449
功能
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
化学信息
分子量Theoretical: 61 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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