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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GM130 Polyclonal Antibody

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货号 TMAB-06591

Anti-GM130 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GM130。Anti-GM130 Polyclonal Antibody 可用于 WB。

Anti-GM130 Polyclonal Antibody

Anti-GM130 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06591

Anti-GM130 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GM130。Anti-GM130 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-GM130 Polyclonal Antibody is a Rabbit antibody targeting GM130. Anti-GM130 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse GM130
抗原种属
Mouse
基因名称
GOLGA2
基因ID
2801
蛋白名称
Golgin subfamily A member 2
功能
Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.
化学信息
分子量Theoretical: 113 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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