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Anti-Glutamate receptor 3 Polyclonal Antibody

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货号 TMAB-06555

Anti-Glutamate receptor 3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Glutamate receptor 3。Anti-Glutamate receptor 3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Glutamate receptor 3 Polyclonal Antibody

Anti-Glutamate receptor 3 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06555

Anti-Glutamate receptor 3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Glutamate receptor 3。Anti-Glutamate receptor 3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-Glutamate receptor 3 Polyclonal Antibody is a Rabbit antibody targeting Glutamate receptor 3. Anti-Glutamate receptor 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression (By similarity).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors) and G-protein coupled (metabotropic) receptors. As such the glutamate receptors play a vital role in the mediation of excitatory synaptic transmission. The ionotropic glutamate receptors are multimeric assemblies of four or five subunits, and are subdivided into three groups (AMPA, NMDA and Kainate receptors) based on their pharmacology structural similarities Glutamate Receptor 3 is a ionotropic, AMPA-selective, membrane bound protein widely distributed in the CNS. Predominant expression is seen in the neuronal cells of the cerebral cortex, dentate gyrus, and glial cells throughout brain regions. AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. Glutamate Receptor 3 exists in 2 named isoforms - Flip and Flop, produced by alternative splicing.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GLUR3
抗原种属
Human
基因名称
GRIA3
基因ID
2892
蛋白名称
Glutamate receptor 3
Uniprot ID
P42263
功能
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
化学信息
分子量Theoretical: 98 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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