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Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2

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货号 TMAB-06536

Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Glucose 6 phosphatase 2。Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 可用于 WB。

Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2

Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-06536

Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Glucose 6 phosphatase 2。Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 is a Rabbit antibody targeting Glucose 6 phosphatase 2. Anti-Glucose 6 phosphatase 2 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Cow,Horse,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Multi-pass membrane protein.
组织特异性Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Glucose 6 phosphatase 2
抗原种属
Human
基因名称
G6PC2
基因ID
57818
蛋白名称
Glucose-6-phosphatase 2
功能
IGRP (islet specific glucose 6 phosphatase catalytic subunit related protein), also known as G6PC2, belongs to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyses the hydrolysis of glucose-6-phosphate. This hydrolysis is the terminal step in gluconeogenic and glycogenolytic pathways, and allows the release of glucose into the bloodstream. IGRP is found in pancreatic islets and does not exhibit phosphohydrolase activity. However, it is a major target of cell-mediated autoimmunity in diabetes.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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