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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GJA8 Polyclonal Antibody

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货号 TMAB-06492

Anti-GJA8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GJA8。Anti-GJA8 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-GJA8 Polyclonal Antibody

Anti-GJA8 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06492

Anti-GJA8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GJA8。Anti-GJA8 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-GJA8 Polyclonal Antibody is a Rabbit antibody targeting GJA8. Anti-GJA8 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Cow,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Cell junction; gap junction.
组织特异性Eye lens.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions (1). Connexin proteins share a common topology of 4 transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop, and cytoplasmic N- and C-termini (2). Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions (2). Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another (2). Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected (3, 2). For instance, deletion of the gene encoding connexin 50, normally expressed in the lens, produces cataracts, though not as severe as with deletion of connexin 46 (4).
抗原信息
免疫原
KLH conjugated synthetic peptide: human GJA8/Connexin 50
抗原种属
Human
基因名称
GJA8
基因ID
2703
蛋白名称
Gap junction alpha-8 protein
Uniprot ID
P48165
功能
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
化学信息
分子量Theoretical: 48 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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