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Anti-GEP100/IQSEC1 Polyclonal Antibody

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货号 TMAB-06437

Anti-GEP100/IQSEC1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GEP100/IQSEC1。Anti-GEP100/IQSEC1 Polyclonal Antibody 可用于 WB。

Anti-GEP100/IQSEC1 Polyclonal Antibody

Anti-GEP100/IQSEC1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06437

Anti-GEP100/IQSEC1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GEP100/IQSEC1。Anti-GEP100/IQSEC1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-GEP100/IQSEC1 Polyclonal Antibody is a Rabbit antibody targeting GEP100/IQSEC1. Anti-GEP100/IQSEC1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic.
组织特异性Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GEP100
抗原种属
Human
基因名称
IQSEC1
基因ID
9922
蛋白名称
IQ motif and SEC7 domain-containing protein 1
Uniprot ID
Q6DN90
功能
In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
化学信息
分子量Theoretical: 108 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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