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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GDNF Receptor alpha 2 Polyclonal Antibody

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货号 TMAB-06413

Anti-GDNF Receptor alpha 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GDNF Receptor alpha 2。Anti-GDNF Receptor alpha 2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-GDNF Receptor alpha 2 Polyclonal Antibody

Anti-GDNF Receptor alpha 2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06413

Anti-GDNF Receptor alpha 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GDNF Receptor alpha 2。Anti-GDNF Receptor alpha 2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-GDNF Receptor alpha 2 Polyclonal Antibody is a Rabbit antibody targeting GDNF Receptor alpha 2. Anti-GDNF Receptor alpha 2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor.
组织特异性Isoform 1 is found in both brain and placenta.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GDNF Receptor alpha 2
抗原种属
Human
基因名称
GFRA2
基因ID
2675
蛋白名称
GDNF family receptor alpha-2
Uniprot ID
O00451
功能
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
化学信息
分子量Theoretical: 47 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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