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Anti-GCK Antibody (5V594)

Name: Anti-GCK Antibody (5V594)
Brand: TargetMol
SKU: TMAB-06384
Rating: 4.5 (1 reviews)

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货号 TMAB-06384

Anti-GCK Antibody (5V594) 是一种 Mouse 抗体，靶向 GCK。Anti-GCK Antibody (5V594) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-GCK Antibody (5V594)

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货号 TMAB-06384

Anti-GCK Antibody (5V594) 是一种 Mouse 抗体，靶向 GCK。Anti-GCK Antibody (5V594) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

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产品描述	Anti-GCK Antibody (5V594) is a Mouse antibody targeting GCK. Anti-GCK Antibody (5V594) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type	IgG1, Kappa
克隆号	5V594
反应种属	Human,Mouse,Rat
应用	WB IHC-P IHC-Fr ICC/IF IF
推荐剂量	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500
抗体种类	Monoclonal
宿主来源	Mouse
组织特异性	Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
构建方式	Recombinant Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度	1mg/ml
研究背景	Hexokinases phosphorylate glucose to produce glucose 6 phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose 6 phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non insulin dependent diabetes mellitus, also called maturity onset diabetes of the young, type 2; mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

抗原信息

基因名称	GCK
基因ID	2645
蛋白名称	Hexokinase-4
功能	Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

储存&溶解度

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式	Shipping with blue ice.
存储	store at low temperature \| -20°C for 1 year

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