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Anti-GABRA1 Polyclonal Antibody
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产品编号 TMAB-00729
别名 Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)
Anti-GABRA1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GABRA1。Anti-GABRA1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。
Anti-GABRA1 Polyclonal Antibody
Anti-GABRA1 Polyclonal Antibody
还可以产品编号 TMAB-00729 别名 Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)
Anti-GABRA1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GABRA1。Anti-GABRA1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,795 | 5日内发货 |
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抗原信息
化学信息
| 产品描述 | Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| 疾病造模方案 | |
| 别名 | Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse) |
| 验证活性 | 1. Sample: Brain (Mouse) Lysate at 40 μg Primary: Anti-GABA A Receptor (TMAB-00729) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa 2. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (TMAB-00729) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 3. Sample: Cerebrum (Mouse) Lysate at 40 μg Cerebellum (Rat) Lysate at 40 μg Primary: Anti-GABRA1/GABA A Receptor alpha 1 (TMAB-00729) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa 4. Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (TMAB-00729) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues a |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
| 免疫原 | KLH conjugated synthetic peptide: human GABRA1 |
| 抗原种属 | Human |
| 基因名称 | GABRA1 |
| 基因ID | |
| 蛋白名称 | gamma-aminobutyric acid receptor subunit alpha-1 |
| Uniprot ID | |
| 功能 | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| 分子量 | Theoretical: 52 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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关键词
γ-aminobutyric acid receptor subunit α-1γ-aminobutyric acid receptor subunit alpha-1γ-aminobutyric acid receptor subunit a-1Gamma-aminobutyric acid receptor subunit α-1Gamma-aminobutyric acid receptor subunit a-1G-aminobutyric acid receptor subunit α-1G-aminobutyric acid receptor subunit alpha-1G-aminobutyric acid receptor subunit a-1GABRA 1GABAAR subunit α-1GABAAR subunit α1GABAAR subunit alpha-1GABAAR subunit alpha1GABAAR subunit a-1GABAAR subunit a1GABA(A) receptor subunit α-1 (GABAAR subunit α-1)GABA(A) receptor subunit a-1 (GABAAR subunit a-1)
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