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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GABBR2 Antibody (8Z785)

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货号 TMAB-06250

Anti-GABBR2 Antibody (8Z785) 是一种 Rabbit 抗体，靶向 GABBR2。Anti-GABBR2 Antibody (8Z785) 可用于 IHC-P,IHC-Fr,IF。

Anti-GABBR2 Antibody (8Z785)

Anti-GABBR2 Antibody (8Z785)

一键复制产品信息
Rating icon 还可以
货号 TMAB-06250

Anti-GABBR2 Antibody (8Z785) 是一种 Rabbit 抗体，靶向 GABBR2。Anti-GABBR2 Antibody (8Z785) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-GABBR2 Antibody (8Z785) is a Rabbit antibody targeting GABBR2. Anti-GABBR2 Antibody (8Z785) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
8Z785
反应种属
Human,Mouse,Rat
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位ell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
组织特异性Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
抗原信息
免疫原
A synthesized peptide: human GABA B receptor 2
抗原种属
Human
基因名称
GABBR2
基因ID
9568
蛋白名称
gamma-aminobutyric acid type B receptor subunit 2
Uniprot ID
O75899
功能
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
化学信息
分子量Theoretical: 103 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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