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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Frizzled 8 Antibody (6A503)

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货号 TMAB-06171

Anti-Frizzled 8 Antibody (6A503) 是一种 Rabbit 抗体，靶向 Frizzled 8。Anti-Frizzled 8 Antibody (6A503) 可用于 IHC-P,IF,IHC-Fr。

Anti-Frizzled 8 Antibody (6A503)

Anti-Frizzled 8 Antibody (6A503)

一键复制产品信息
Rating icon 还可以
货号 TMAB-06171

Anti-Frizzled 8 Antibody (6A503) 是一种 Rabbit 抗体，靶向 Frizzled 8。Anti-Frizzled 8 Antibody (6A503) 可用于 IHC-P,IF,IHC-Fr。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Frizzled 8 Antibody (6A503) is a Rabbit antibody targeting Frizzled 8. Anti-Frizzled 8 Antibody (6A503) can be used in IHC-P,IF,IHC-Fr.
Ig Type
IgG
克隆号
6A503
反应种属
Human,Mouse,Rat
应用IHC-PIFIHC-Fr
推荐剂量
IHC-P: 1:100-500; IF: 1:100-500; IHC-Fr: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Membrane. Golgi apparatus. Cell membrane. Colocalizes with GOPC at the Golgi apparatus.
组织特异性Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the Beta-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.
抗原信息
免疫原
A synthesized peptide: human Frizzled 8
抗原种属
Human
基因名称
FZD8
基因ID
8325
蛋白名称
Frizzled-8
Uniprot ID
Q9H461
功能
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1
化学信息
分子量Theoretical: 70 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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