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Anti-FRAT2 Polyclonal Antibody

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货号 TMAB-06160

Anti-FRAT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FRAT2。Anti-FRAT2 Polyclonal Antibody 可用于 FCM。

Anti-FRAT2 Polyclonal Antibody

Anti-FRAT2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06160

Anti-FRAT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FRAT2。Anti-FRAT2 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-FRAT2 Polyclonal Antibody is a Rabbit antibody targeting FRAT2. Anti-FRAT2 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Cow,Sheep)
验证活性
Blank control: Mouse spleen.
Primary Antibody (green line): Rabbit Anti-FRAT2 antibody (TMAB-06160)
Dilution: 2 μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG.
Secondary Antibody: Goat anti-rabbit IgG-AF488
Dilution: 1 μg /test.
Protocol
The cells were fixed with 70% ethanol (10 min at room temperature) and then were incubated in 5% BSA to block non-specific protein-protein interactions for 30 min at room temperature. Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
应用FCM
推荐剂量
FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FRAT2
抗原种属
Human
基因名称
FRAT2
基因ID
23401
蛋白名称
GSK-3-binding protein FRAT2
Uniprot ID
O75474
功能
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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