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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FRAT2 Polyclonal Antibody

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货号 TMAB-06160

Anti-FRAT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FRAT2。Anti-FRAT2 Polyclonal Antibody 可用于 FCM。

Anti-FRAT2 Polyclonal Antibody

Anti-FRAT2 Polyclonal Antibody

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货号 TMAB-06160

Anti-FRAT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FRAT2。Anti-FRAT2 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-FRAT2 Polyclonal Antibody is a Rabbit antibody targeting FRAT2. Anti-FRAT2 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Cow,Sheep)
应用FCM
推荐剂量
FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FRAT2
抗原种属
Human
基因名称
FRAT2
基因ID
23401
蛋白名称
GSK-3-binding protein FRAT2
Uniprot ID
O75474
功能
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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