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别名 FMC63-scFv, FMC63-CD19, FMC63 scFv, FMC 63, Anti-CD19 (FMC63) CAR, Anti-CD19 (FMC63)
Anti-FMC63 Antibody (5N304) 是一种 Rabbit 抗体,靶向 FMC63。Anti-FMC63 Antibody (5N304) 可用于 ELISA, FCM。
Anti-FMC63 Antibody (5N304) 是一种 Rabbit 抗体,靶向 FMC63。Anti-FMC63 Antibody (5N304) 可用于 ELISA, FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 T | ¥ 19,500 | 5日内发货 |
| 产品描述 | Anti-FMC63 Antibody (5N304) is a Rabbit antibody targeting FMC63. Anti-FMC63 Antibody (5N304) can be used in ELISA, FCM. |
| 别名 | FMC63-scFv, FMC63-CD19, FMC63 scFv, FMC 63, Anti-CD19 (FMC63) CAR, Anti-CD19 (FMC63) |
| Ig Type | IgG, κ |
| 克隆号 | 5N304 |
| 特异性 | FMC63 scFv and CARs derived from FMC63 scFv |
| 应用 | ELISAFCM |
| 推荐剂量 | ELISA: 1:1,000-1:10,000; FCM: 1:50 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 纯化方式 | Protein A affinity column |
| 性状 | Liquid |
| 缓冲液 | Supplied in PBS, pH 7.2, 0.03% ProClin300 and 50% glycerol. |
| 研究背景 | The FMC63 scFv (single-chain variable fragment) is a key component in many chimeric antigen receptor (CAR) designs, particularly in CAR-T cell therapies. Derived from a murine monoclonal antibody, FMC63 specifically targets human CD19, a cell surface protein highly expressed on B-cells, including malignant B-cells in B-cell leukemias and lymphomas. This scFv fragment is engineered by fusing the variable regions of the heavy and light chains of the antibody, preserving the antigen-binding capability while significantly reducing its size. This smaller, single-chain format enhances its integration into CAR constructs, enabling the recognition and destruction of CD19-positive cells by CAR-T cells. FMC63-based CARs are widely used in immunotherapy, particularly in FDA-approved treatments for B-cell malignancies, such as Kymriah® and Yescarta®. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | iFluor 647 |
| 可提供抗体种类 | 2 |
| 免疫原 | FMC63 scFv |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | -20°C for 1 year |