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Anti-FMC63 Antibody (5N304)

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货号 TMAS-00042

别名 FMC63-scFv, FMC63-CD19, FMC63 scFv, FMC 63, Anti-CD19 (FMC63) CAR, Anti-CD19 (FMC63)

Anti-FMC63 Antibody (5N304) 是一种 Rabbit 抗体,靶向 FMC63。Anti-FMC63 Antibody (5N304) 可用于 ELISA, FCM。

Anti-FMC63 Antibody (5N304)

Anti-FMC63 Antibody (5N304)

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Rating icon 还可以
货号 TMAS-00042 别名 FMC63-scFv, FMC63-CD19, FMC63 scFv, FMC 63, Anti-CD19 (FMC63) CAR, Anti-CD19 (FMC63)

Anti-FMC63 Antibody (5N304) 是一种 Rabbit 抗体,靶向 FMC63。Anti-FMC63 Antibody (5N304) 可用于 ELISA, FCM。

规格价格库存数量
100 T
¥ 19,500
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产品介绍


生物活性
产品描述
Anti-FMC63 Antibody (5N304) is a Rabbit antibody targeting FMC63. Anti-FMC63 Antibody (5N304) can be used in ELISA, FCM.
别名FMC63-scFv, FMC63-CD19, FMC63 scFv, FMC 63, Anti-CD19 (FMC63) CAR, Anti-CD19 (FMC63)
Ig Type
IgG, κ
克隆号
5N304
特异性
FMC63 scFv and CARs derived from FMC63 scFv
应用ELISAFCM
推荐剂量
ELISA: 1:1,000-1:10,000; FCM: 1:50
抗体种类
Monoclonal
宿主来源Rabbit
纯化方式Protein A affinity column
性状Liquid
缓冲液Supplied in PBS, pH 7.2, 0.03% ProClin300 and 50% glycerol.
研究背景The FMC63 scFv (single-chain variable fragment) is a key component in many chimeric antigen receptor (CAR) designs, particularly in CAR-T cell therapies. Derived from a murine monoclonal antibody, FMC63 specifically targets human CD19, a cell surface protein highly expressed on B-cells, including malignant B-cells in B-cell leukemias and lymphomas. This scFv fragment is engineered by fusing the variable regions of the heavy and light chains of the antibody, preserving the antigen-binding capability while significantly reducing its size. This smaller, single-chain format enhances its integration into CAR constructs, enabling the recognition and destruction of CD19-positive cells by CAR-T cells. FMC63-based CARs are widely used in immunotherapy, particularly in FDA-approved treatments for B-cell malignancies, such as Kymriah® and Yescarta®.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
iFluor 647
可提供抗体种类
2
抗原信息
免疫原
FMC63 scFv
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储-20°C for 1 year

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