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Anti-FKBP52 Antibody (9Z540)

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货号 TMAB-06049

Anti-FKBP52 Antibody (9Z540) 是一种 Mouse 抗体，靶向 FKBP52。Anti-FKBP52 Antibody (9Z540) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-FKBP52 Antibody (9Z540)

Anti-FKBP52 Antibody (9Z540)

一键复制产品信息
Rating icon 还可以
货号 TMAB-06049

Anti-FKBP52 Antibody (9Z540) 是一种 Mouse 抗体，靶向 FKBP52。Anti-FKBP52 Antibody (9Z540) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-FKBP52 Antibody (9Z540) is a Mouse antibody targeting FKBP52. Anti-FKBP52 Antibody (9Z540) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG1, Kappa
克隆号
9Z540
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-1000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm; cytosol. Nucleus. Cytoplasm; cytoskeleton.
组织特异性Widely expressed.
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
抗原信息
基因名称
FKBP4
基因ID
2288
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP4
功能
Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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