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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FKBP51 Polyclonal Antibody

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货号 TMAB-06048

Anti-FKBP51 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FKBP51。Anti-FKBP51 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-FKBP51 Polyclonal Antibody

Anti-FKBP51 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06048

Anti-FKBP51 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FKBP51。Anti-FKBP51 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-FKBP51 Polyclonal Antibody is a Rabbit antibody targeting FKBP51. Anti-FKBP51 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
组织特异性Widely expressed, enriched in testis compared to other tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin (1). Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin (2,3). The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGF?type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGF?pathway (4). FKBP51 and FKBP52 are two highly related proteins (5,6). FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids (5). FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation (7). FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).
抗原信息
免疫原
KLH conjugated synthetic peptide: human FKBP51
抗原种属
Human
基因名称
FKBP5
基因ID
2289
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP5
Uniprot ID
Q13451
功能
Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
化学信息
分子量Theoretical: 51 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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