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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FKBP38 Polyclonal Antibody

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货号 TMAB-06046

Anti-FKBP38 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FKBP38。Anti-FKBP38 Polyclonal Antibody 可用于 WB。

Anti-FKBP38 Polyclonal Antibody

Anti-FKBP38 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06046

Anti-FKBP38 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FKBP38。Anti-FKBP38 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-FKBP38 Polyclonal Antibody is a Rabbit antibody targeting FKBP38. Anti-FKBP38 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Mitochondrion membrane.
组织特异性Widely expressed. Highest levels seen in the brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景FKBP8 is an immunophilin family member lacking PPIase/arotamase activity that influences immunoregulation, protein folding and trafficking in neurons associated with memory function. The FKBPr38 form derives from a truncated ORF. Presenilin 1 and 2 form molecular complexes with anti-apoptotic Bcl-2, and promote degradation of FKBP38 and Bcl-2, and sequester these proteins in ER/Golgi, thereby inhibiting FKBPr38-mediated, γ-secretase-independent, mitochondrial targeting of Bcl-2. FKBP8 present in the central nervous system can antagonize hedgehog (HH) signaling, where HH is critical for patterning and growth of many tissues in the developing embryo. Mouse FKBPr38 mRNA is present in neurons and glial cells and appears more pronounced in neurons associated with the hippocampal formation in adult mouse brains.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FKBP38
抗原种属
Human
基因名称
FKBP8
基因ID
23770
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP8
Uniprot ID
Q14318
功能
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
化学信息
分子量Theoretical: 46 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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