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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FISH Polyclonal Antibody

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货号 TMAB-06037

Anti-FISH Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FISH。Anti-FISH Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-FISH Polyclonal Antibody

Anti-FISH Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06037

Anti-FISH Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FISH。Anti-FISH Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-FISH Polyclonal Antibody is a Rabbit antibody targeting FISH. Anti-FISH Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell projection > podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
组织特异性Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo; catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).
抗原信息
免疫原
KLH conjugated synthetic peptide: human FISH
抗原种属
Human
基因名称
SH3PXD2A
基因ID
9644
蛋白名称
SH3 and PX domain-containing protein 2A
Uniprot ID
Q5TCZ1
功能
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
化学信息
分子量Theoretical: 125 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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