Name: Anti-FGF19 Antibody (1A6)
Brand: TargetMol
SKU: T9901A-1351
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-FGF19 Antibody (1A6) represents a highly specialized monoclonal antibody specifically engineered to target the human fibroblast growth factor 19 with exceptional binding affinity. It effectively facilitates the measurable neutralization of FGF19-mediated signaling across various preclinical experimental models to evaluate the blockade of the FGFR4/beta-Klotho complex during strictly monitored laboratory observation periods and functional cell signaling assays to ensure high experimental sensitivity in molecular oncology.
体外活性	在人肝细胞癌细胞系（如 Hep3B）中，Anti-FGF19 Antibody (1A6) 阻断了由 FGF19 诱导的 FGFR4 自身磷酸化，并抑制了细胞集落形成 [1]。
体内活性	在人肝细胞癌异种移植模型及 FGF19 转基因小鼠模型中，通过全身给药方式给予 Anti-FGF19 Antibody (1A6) 显著抑制了肿瘤生长 [1]。
别名	抗FGF19抗体(1A6), 1A6
克隆号	1A6
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	O95750
靶点	FGF19

储存&溶解度

存储

Anti-FGF19 Antibody (1A6)