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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FGD3 Polyclonal Antibody

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货号 TMAB-05977

Anti-FGD3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FGD3。Anti-FGD3 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-FGD3 Polyclonal Antibody

Anti-FGD3 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05977

Anti-FGD3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FGD3。Anti-FGD3 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-FGD3 Polyclonal Antibody is a Rabbit antibody targeting FGD3. Anti-FGD3 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cytoplasm > cytoskeleton.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景FGD1 gene mutations result in faciogenital dysplasia (FGDY, Aarskog-Scott syndrome), an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures. FGD1 maps to human chromosome Xp11.21 and shares a high degree of sequence identity with the FGD2 (6p21.2) and the FGD3 (9q22.31) proteins. FGD1 encodes a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42. FGD2 is present in several diverse tissues during embryogenesis, suggesting a role in embryonic development. FGD3 stimulates fibroblasts to form filopodia, which are Actin microspikes formed upon the stimulation of Cdc42. All FGD family members contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins control essential signals required during embryonic development.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FGD3
抗原种属
Human
基因名称
FGD3
基因ID
89846
蛋白名称
FYVE, RhoGEF and PH domain-containing protein 3
Uniprot ID
Q5JSP0
功能
Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
化学信息
分子量Theoretical: 79 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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