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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FEZ1 Polyclonal Antibody

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货号 TMAB-05973

Anti-FEZ1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FEZ1。Anti-FEZ1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-FEZ1 Polyclonal Antibody

Anti-FEZ1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05973

Anti-FEZ1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FEZ1。Anti-FEZ1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-FEZ1 Polyclonal Antibody is a Rabbit antibody targeting FEZ1. Anti-FEZ1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytoskeleton, centrosome. Cellmembrane (By similarity). Note=Co-localizes with both, alpha- andgamma-tubulin. Translocated from the plasma membrane to thecytoplasm by activation of the PKC zeta (By similarity).
组织特异性Mainly expressed in brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FEZ1
抗原种属
Human
基因名称
FEZ1
基因ID
9638
蛋白名称
Fasciculation and elongation protein zeta-1
Uniprot ID
Q99689
功能
May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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