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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FE65 Antibody (4D725)

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货号 TMAB-05960

Anti-FE65 Antibody (4D725) 是一种 Rabbit 抗体，靶向 FE65。Anti-FE65 Antibody (4D725) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-FE65 Antibody (4D725)

Anti-FE65 Antibody (4D725)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05960

Anti-FE65 Antibody (4D725) 是一种 Rabbit 抗体，靶向 FE65。Anti-FE65 Antibody (4D725) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-FE65 Antibody (4D725) is a Rabbit antibody targeting FE65. Anti-FE65 Antibody (4D725) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
4D725
反应种属
Human
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Cytoplasm. Nucleus. Cellprojection, growth cone (By similarity). Nucleus speckle.Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity).In normal conditions, it mainly localizes to the cytoplasm, while asmall fraction is tethered to the cell membrane via its interactionwith APP. Following exposure to DNA damaging agents, it is releasedfrom cell membrane and translocates to the nucleus. Nucleartranslocation is under the regulation of APP. Colocalizes withTSHZ3 in the nucleus. Co-localizes with NEK6 at the nuclearspeckles. Phosphorylation at Ser-610 by SGK1 promotes itslocalization to the nucleus
组织特异性Highly expressed in brain; strongly reduced inpost-mortem elderly subjects with Alzheimer disease.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Transcription coregulator that can have both coactivator and corepressor functions.
抗原信息
免疫原
A synthesized peptide: human FE65
抗原种属
Human
基因名称
APBB1
基因ID
322
蛋白名称
Amyloid-beta A4 precursor protein-binding family B member 1
Uniprot ID
O00213
功能
Transcription coregulator that can have both coactivatorand corepressor functions. Adapter protein that forms atranscriptionally active complex with the gamma-secretase-derivedamyloid precursor protein (APP) intracellular domain. Plays acentral role in the response to DNA damage by translocating to thenucleus and inducing apoptosis. May act by specifically recognizingand binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph)at double-strand breaks (DSBs), recruiting other pro-apoptosisfactors such as MAPK8/JNK1. Required for histone H4 acetylation atdouble-strand breaks (DSBs). Its ability to specifically bindmodified histones and chromatin modifying enzymes such asKAT5/TIP60, probably explains its trancription activation activity.Function in association with TSHZ3, SET and HDAC factors as atranscriptional repressor, that inhibits the expression of CASP4.Associates with chromatin in a region surrounding the CASP4transcriptional start site(s).
化学信息
分子量Theoretical: 77 kDa. Actual: 100 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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