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Anti-Fas/CD95 Antibody (2C992)
还可以产品编号 TMAY-03725
Anti-Fas/CD95 Antibody (2C992) 是一种 Rabbit 抗体，靶向 Fas/CD95。Anti-Fas/CD95 Antibody (2C992) 可用于 FCM。
Anti-Fas/CD95 Antibody (2C992)
Anti-Fas/CD95 Antibody (2C992)
还可以产品编号 TMAY-03725
Anti-Fas/CD95 Antibody (2C992) 是一种 Rabbit 抗体，靶向 Fas/CD95。Anti-Fas/CD95 Antibody (2C992) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Fas/CD95 Antibody (2C992) is a Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody (2C992) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2C992 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of Rat FAS(CD95) expression on SD rat splenocytes. Cells were stained with purified anti-Rat FAS(CD95), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD95 / APO-1 / TNFRSF6 / FAS (rR CD95 / APO-1 / TNFRSF6 / FAS; TMPY-02057; NP_631933.2; Met1-Lys170). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | PE |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Rat CD95 / APO-1 / TNFRSF6 / FAS Protein (TMPY-02057) |
| 抗原种属 | Rat |
| 研究领域 | Tumor Suppressors |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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