Name: Anti-F8/Factor VIII Antibody
Brand: TargetMol
SKU: T9901A-1275
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-F8/Factor VIII Antibody is a CHO-expressed humanized monoclonal antibody. This product binds specifically to Coagulation Factor VIII (F8) with high affinity, blocking its cofactor function in the coagulation cascade. Featuring a huIgG4 heavy chain and huκ light chain, it serves as an important pharmacological tool for researching Hemophilia A, inhibitor formation, and the regulation of blood coagulation.
体外活性	在生化和中和实验中，Anti-F8/Factor VIII Antibody表现出对人凝血因子 VIII 重链和/或轻链的高度结合特异性，并能以浓度依赖性方式在显色或凝固实验中有效中和其促凝活性 [1]。
体内活性	在利用血友病 A 小鼠模型或灵长类动物进行的药理学研究中，系统给予抗Anti-F8/Factor VIII Antibody被用于评估 F8 的清除动力学及 F8 抑制物的诱导；结果证实，该抗体能有效调节 F8 血浆水平，并有助于研究免疫介导的凝血因子失活机制 [1][2]。
别名	抗F8/Factor VIII抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P00451
靶点	F8/FactorVIII

储存&溶解度

存储

Anti-F8/Factor VIII Antibody