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Anti-Estrogen Related Receptor gamma Polyclonal Antibody

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货号 TMAB-05709

Anti-Estrogen Related Receptor gamma Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Estrogen Related Receptor gamma。Anti-Estrogen Related Receptor gamma Polyclonal Antibody 可用于 WB。

Anti-Estrogen Related Receptor gamma Polyclonal Antibody

Anti-Estrogen Related Receptor gamma Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05709

Anti-Estrogen Related Receptor gamma Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Estrogen Related Receptor gamma。Anti-Estrogen Related Receptor gamma Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍


生物活性
产品描述
Anti-Estrogen Related Receptor gamma Polyclonal Antibody is a Rabbit antibody targeting Estrogen Related Receptor gamma. Anti-Estrogen Related Receptor gamma Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus
组织特异性Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ESRRG/Estrogen Related Receptor gamma
抗原种属
Human
基因名称
ESRRG
基因ID
蛋白名称
Estrogen-related receptor gamma
Uniprot ID
功能
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements
化学信息
分子量Theoretical: 51 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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