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Anti-Estrogen Related Receptor gamma Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Estrogen Related Receptor gamma。Anti-Estrogen Related Receptor gamma Polyclonal Antibody 可用于 WB。
Anti-Estrogen Related Receptor gamma Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Estrogen Related Receptor gamma。Anti-Estrogen Related Receptor gamma Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,970 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
| 产品描述 | Anti-Estrogen Related Receptor gamma Polyclonal Antibody is a Rabbit antibody targeting Estrogen Related Receptor gamma. Anti-Estrogen Related Receptor gamma Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| 反应种属 | Mouse,Rat (predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nucleus |
| 组织特异性 | Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. |
| 免疫原 | KLH conjugated synthetic peptide: human ESRRG/Estrogen Related Receptor gamma |
| 抗原种属 | Human |
| 基因名称 | ESRRG |
| 基因ID | |
| 蛋白名称 | Estrogen-related receptor gamma |
| Uniprot ID | |
| 功能 | Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements |
| 分子量 | Theoretical: 51 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |