Anti-ERO1L Antibody (8X1)

Name: Anti-ERO1L Antibody (8X1)
Brand: TargetMol
SKU: TMAB-05679
Rating: 4.5 (1 reviews)

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货号 TMAB-05679

Anti-ERO1L Antibody (8X1) 是一种 Mouse 抗体，靶向 ERO1L。Anti-ERO1L Antibody (8X1) 可用于 WB,ICC/IF。

Anti-ERO1L Antibody (8X1)

一键复制产品信息

还可以

货号 TMAB-05679

Anti-ERO1L Antibody (8X1) 是一种 Mouse 抗体，靶向 ERO1L。Anti-ERO1L Antibody (8X1) 可用于 WB,ICC/IF。

规格	价格	库存
25 μL	¥ 795	5日内发货
50 μL	¥ 1,390	5日内发货
100 μL	¥ 2,485	5日内发货

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产品介绍

生物活性

产品描述	Anti-ERO1L Antibody (8X1) is a Mouse antibody targeting ERO1L. Anti-ERO1L Antibody (8X1) can be used in WB,ICC/IF.
Ig Type	IgG2b/Kappa
克隆号	8X1
反应种属	Human
应用	WB ICC/IF
推荐剂量	WB: 1:1000-5000; ICC/IF: 1:100-500
抗体种类	Monoclonal
宿主来源	Mouse
亚细胞定位	Endoplasmic reticulum membrane. The association with ERP44 is essential for its retention in the endoplasmic reticulum.
组织特异性	Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.
构建方式	Recombinant Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度	1mg/ml
研究背景	Ero1-La is an essential oxidoreductase that oxidizes proteins and is required for the folding of immunoglobulins. Ero-1La covalently binds with PDI (protein disulfide-isomerase) and together they produce disulfide bonds between proteins in the endoplasmic reticulum. Ero1-La and SIRT1 regulate adiponectin secretion from adipose tissue. Ero1-La and associated proteins also modulate PPARg (peroxisome proliferator-activated receptor g) and SIRT1 activities. Ero1-La is stimulated by hypoxia, suggesting that it is regulated through the HIF (hypoxia inducible transcrip-tion factor) pathway. Ero1-La is ubiquitously expressed at low levels but expressed at high levels in upper digestive tract and esophagus. Ero1-La may function both as a monomer and a homodimer.

抗原信息

基因名称	ERO1A
基因ID	30001
蛋白名称	ERO1-like protein alpha
功能	Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.

储存&溶解度

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式	Shipping with blue ice.
存储	store at low temperature \| -20°C for 1 year