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Anti-ERCC8 Antibody (1V748) 是一种 Rabbit 抗体,靶向 ERCC8。Anti-ERCC8 Antibody (1V748) 可用于 WB,IP。
Anti-ERCC8 Antibody (1V748) 是一种 Rabbit 抗体,靶向 ERCC8。Anti-ERCC8 Antibody (1V748) 可用于 WB,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μL | ¥ 795 | 5日内发货 | |
| 50 μL | ¥ 1,385 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
| 产品描述 | Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP. |
| Ig Type | IgG |
| 克隆号 | 1V748 |
| 反应种属 | Human |
| 应用 | WBIP |
| 推荐剂量 | WB: 1:500-2000; IP: 1:20-50 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究背景 | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. |
| 免疫原 | A synthesized peptide: human ERCC8 |
| 抗原种属 | Human |
| 基因名称 | ERCC8 |
| 基因ID | |
| 蛋白名称 | DNA excision repair protein ERCC-8 |
| Uniprot ID | |
| 功能 | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. |
| 分子量 | Theoretical: 44 kDa. Actual: 44 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |