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Anti-ERCC8 Antibody (1V748)

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货号 TMAB-05660

Anti-ERCC8 Antibody (1V748) 是一种 Rabbit 抗体,靶向 ERCC8。Anti-ERCC8 Antibody (1V748) 可用于 WB,IP。

Anti-ERCC8 Antibody (1V748)

Anti-ERCC8 Antibody (1V748)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05660

Anti-ERCC8 Antibody (1V748) 是一种 Rabbit 抗体,靶向 ERCC8。Anti-ERCC8 Antibody (1V748) 可用于 WB,IP。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍


生物活性
产品描述
Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP.
Ig Type
IgG
克隆号
1V748
反应种属
Human
应用WBIP
推荐剂量
WB: 1:500-2000; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
抗原信息
免疫原
A synthesized peptide: human ERCC8
抗原种属
Human
基因名称
ERCC8
基因ID
蛋白名称
DNA excision repair protein ERCC-8
Uniprot ID
功能
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
化学信息
分子量Theoretical: 44 kDa. Actual: 44 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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