Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP.

IgG

1V748

Human

25 μg total protein per lane of various lysates (see on figure) probed with ERCC8 monoclonal antibody, unconjugated (TMAB-05660) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

WB: 1:500-2000; IP: 1:20-50

Monoclonal

A synthesized peptide: human ERCC8

Human

ERCC8

DNA excision repair protein ERCC-8

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.