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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Epsin 2 Polyclonal Antibody

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货号 TMAB-05640

Anti-Epsin 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epsin 2。Anti-Epsin 2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Epsin 2 Polyclonal Antibody

Anti-Epsin 2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05640

Anti-Epsin 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epsin 2。Anti-Epsin 2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Epsin 2 Polyclonal Antibody is a Rabbit antibody targeting Epsin 2. Anti-Epsin 2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Cow,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cytoplasmic vesicle; clathrin-coated vesicle. In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
组织特异性Highest expression is found in brain. Detected at lower levels in lung and liver.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates have been described, designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15. Epsin is a binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrin-mediated endocytosis. Epsin, along with its binding partner Eps15, is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2a, and 2b are splicing variants of epsin 2, which is associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Epsin 2
抗原种属
Human
基因名称
EPN2
基因ID
22905
蛋白名称
EPN1
Uniprot ID
O95208
功能
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
化学信息
分子量Theoretical: 69 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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