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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Epsin 1 Polyclonal Antibody

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货号 TMAB-05639

Anti-Epsin 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epsin 1。Anti-Epsin 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-Epsin 1 Polyclonal Antibody

Anti-Epsin 1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05639

Anti-Epsin 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epsin 1。Anti-Epsin 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-Epsin 1 Polyclonal Antibody is a Rabbit antibody targeting Epsin 1. Anti-Epsin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Horse,Sheep)
应用IHC-PIHC-FrICC/IFIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Epsin 1 is an endocytic accessory protein, with significant similarity to the Xenopus mitotic phosphoprotein MP90. Epsin 1 interacts with Eps15 (the ?subunit of the Clathrin adaptor AP2), Clathrin and other accessory proteins. The mitotic phosphorylation of these proteins may be one of the mechanisms by which the invagination of Clathrin-coated pits is blocked in mitosis. Both Epsin and Eps15, like other cytosolic components of the synaptic vesicle endo-cytic machinery, undergo constitutive phosphorylation and depolarization-dependent dephosphorylation in nerve terminals. Epsin 1 also contributes to the mechanism of Clathrin-vesicle-dependent endocytosis. The human Epsin 1 protein contains an Epsin N-terminal homology (ENTH) region and a single Clathrin-binding (LVDLD) motif. Epsin 1 localizes to the leading edge of a vesicular coated pit where the membrane is being actively bent.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Epsin 1/EPN1
抗原种属
Human
基因名称
EPN1
基因ID
29924
蛋白名称
Epsin-1
Uniprot ID
Q9Y6I3
功能
Epsin 1 is a cytosolic adaptor protein and interacting partner for the EH domain containing region of Eps15. It is involved in the regulation of clathrin mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15. Epsin 1 is a cargo specific adaptor for influenza virus entry through the clathrin mediated pathway. In addition to being a clathrin interacting protiein, Epsin 1 is also an ubiquitin, and phospholipid interacting protein. It also may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function.
化学信息
分子量Theoretical: 60 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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