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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Ephexin-1 Polyclonal Antibody

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货号 TMAB-05626

Anti-Ephexin-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Ephexin-1。Anti-Ephexin-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Ephexin-1 Polyclonal Antibody

Anti-Ephexin-1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05626

Anti-Ephexin-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Ephexin-1。Anti-Ephexin-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-Ephexin-1 Polyclonal Antibody is a Rabbit antibody targeting Ephexin-1. Anti-Ephexin-1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Membrane. Cell projection, growth cone. Associated with membranes. Localizes to axonal growth cones.
组织特异性Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.
抗原信息
免疫原
KLH conjugated synthetic peptide: human EPHEXIN
抗原种属
Human
基因名称
NGEF
基因ID
25791
蛋白名称
Ephexin-1
Uniprot ID
Q8N5V2
功能
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension.
化学信息
分子量Theoretical: 82 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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