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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Epac2 Polyclonal Antibody

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货号 TMAB-05602

Anti-Epac2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epac2。Anti-Epac2 Polyclonal Antibody 可用于 WB。

Anti-Epac2 Polyclonal Antibody

Anti-Epac2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05602

Anti-Epac2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Epac2。Anti-Epac2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Epac2 Polyclonal Antibody is a Rabbit antibody targeting Epac2. Anti-Epac2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Membrane.
组织特异性Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the ras family GTPases Rap1 and Rap2 by promoting GTP binding in a cAMP-dependent manner (1,2). Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission (3). Human EPAC2 contains at least 31 exons and maps to chromosome 2q31 (4). The 4.4-kb Epac2 transcript is prominent in brain and adrenal gland (5,6). Within the brain, expression is strong in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus and cerebellum (5,6).
抗原信息
免疫原
KLH conjugated synthetic peptide: human Epac2
抗原种属
Human
基因名称
RAPGEF4
基因ID
11069
蛋白名称
Rap guanine nucleotide exchange factor 4
Uniprot ID
Q8WZA2
功能
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
化学信息
分子量Theoretical: 116 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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