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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-EDA2R Polyclonal Antibody

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货号 TMAB-05434

Anti-EDA2R Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EDA2R。Anti-EDA2R Polyclonal Antibody 可用于 WB。

Anti-EDA2R Polyclonal Antibody

Anti-EDA2R Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05434

Anti-EDA2R Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EDA2R。Anti-EDA2R Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-EDA2R Polyclonal Antibody is a Rabbit antibody targeting EDA2R. Anti-EDA2R Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type III membrane protein.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8).
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse EDA2R
抗原种属
Mouse
基因名称
EDA2R
基因ID
245527
蛋白名称
Tumor necrosis factor receptor superfamily member 27
Uniprot ID
Q8BX35
功能
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
化学信息
分子量Theoretical: 33 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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