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Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578)
还可以产品编号 TMAY-02907
Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) 是一种 Mouse 抗体，靶向 Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP。Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) 可用于 ELISA。
Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578)
Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578)
还可以产品编号 TMAY-02907
Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) 是一种 Mouse 抗体，靶向 Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP。Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) 可用于 ELISA。
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| 产品描述 | Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) is a Mouse antibody targeting Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP. Anti-Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Antibody (1J578) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1J578 |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP ( TMPY-00038; AAC54887.1; Met1-Gln650). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The fourth gene of the EBOV genome encodes a 16-kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP Protein (TMPY-00038) |
| 抗原种属 | EBOV |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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