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Anti-E2F1 Polyclonal Antibody 2

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货号 TMAB-05385

Anti-E2F1 Polyclonal Antibody 2 是一种 Rabbit 抗体,靶向 E2F1。Anti-E2F1 Polyclonal Antibody 2 可用于 WB。

Anti-E2F1 Polyclonal Antibody 2

Anti-E2F1 Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-05385

Anti-E2F1 Polyclonal Antibody 2 是一种 Rabbit 抗体,靶向 E2F1。Anti-E2F1 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍


生物活性
产品描述
Anti-E2F1 Polyclonal Antibody 2 is a Rabbit antibody targeting E2F1. Anti-E2F1 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human E2F1
抗原种属
Human
基因名称
E2F1
基因ID
蛋白名称
Transcription factor E2F1
Uniprot ID
功能
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.
化学信息
分子量Theoretical: 46 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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