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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Drebrin Polyclonal Antibody

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货号 TMAB-05319

Anti-Drebrin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Drebrin。Anti-Drebrin Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Drebrin Polyclonal Antibody

Anti-Drebrin Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05319

Anti-Drebrin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Drebrin。Anti-Drebrin Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Drebrin Polyclonal Antibody is a Rabbit antibody targeting Drebrin. Anti-Drebrin Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Drebrin is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites. Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the adult brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Drebrin
抗原种属
Human
基因名称
DBN1
基因ID
1627
蛋白名称
Drebrin
Uniprot ID
Q16643
功能
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.
化学信息
分子量Theoretical: 71 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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