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Anti-Doublin Antibody (6Y232)

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货号 TMAB-05293

Anti-Doublin Antibody (6Y232) 是一种 Rabbit 抗体,靶向 Doublin。Anti-Doublin Antibody (6Y232) 可用于 WB。

Anti-Doublin Antibody (6Y232)

Anti-Doublin Antibody (6Y232)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05293

Anti-Doublin Antibody (6Y232) 是一种 Rabbit 抗体,靶向 Doublin。Anti-Doublin Antibody (6Y232) 可用于 WB。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
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100 μL
¥ 2,480
5日内发货
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产品介绍


生物活性
产品描述
Anti-Doublin Antibody (6Y232) is a Rabbit antibody targeting Doublin. Anti-Doublin Antibody (6Y232) can be used in WB.
Ig Type
IgG
克隆号
6Y232
反应种属
Mouse,Rat (predicted:Human)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell projection. Note=Localizes at neurite tips.
组织特异性Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, and occurs at the same time that these cells begin to express, a marker for mature neurons. Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise, which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis.
抗原信息
免疫原
A synthesized peptide: human Doublin
抗原种属
Human
基因名称
DCX
基因ID
蛋白名称
Neuronal migration protein doublecortin
Uniprot ID
功能
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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