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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DOK7 Polyclonal Antibody

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货号 TMAB-05281

Anti-DOK7 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DOK7。Anti-DOK7 Polyclonal Antibody 可用于 WB。

Anti-DOK7 Polyclonal Antibody

Anti-DOK7 Polyclonal Antibody

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货号 TMAB-05281

Anti-DOK7 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DOK7。Anti-DOK7 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-DOK7 Polyclonal Antibody is a Rabbit antibody targeting DOK7. Anti-DOK7 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Cell junction > synapse. Accumulates at neuromuscular junctions.
组织特异性Preferentially expressed in skeletal muscle and heart Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) — recessively inherited disorders characterized by muscle weakness.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DOK7
抗原种属
Human
基因名称
DOK7
基因ID
285489
蛋白名称
Protein Dok-7
Uniprot ID
Q18PE1
功能
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
化学信息
分子量Theoretical: 53 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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