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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Dnmt3L Polyclonal Antibody

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货号 TMAB-05264

Anti-Dnmt3L Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Dnmt3L。Anti-Dnmt3L Polyclonal Antibody 可用于 WB。

Anti-Dnmt3L Polyclonal Antibody

Anti-Dnmt3L Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05264

Anti-Dnmt3L Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Dnmt3L。Anti-Dnmt3L Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Dnmt3L Polyclonal Antibody is a Rabbit antibody targeting Dnmt3L. Anti-Dnmt3L Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Expressed at low levels in several tissues including testis, ovary, and thymus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Dnmt3L
抗原种属
Human
基因名称
DNMT3L
基因ID
29947
蛋白名称
DNA(cytosine-5)-methyltransferase 3-like
Uniprot ID
Q9UJW3
功能
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
化学信息
分子量Theoretical: 44 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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