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Anti-DNA Polymerase iota Polyclonal Antibody

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货号 TMAB-05219

Anti-DNA Polymerase iota Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DNA Polymerase iota。Anti-DNA Polymerase iota Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-DNA Polymerase iota Polyclonal Antibody

Anti-DNA Polymerase iota Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05219

Anti-DNA Polymerase iota Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DNA Polymerase iota。Anti-DNA Polymerase iota Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-DNA Polymerase iota Polyclonal Antibody is a Rabbit antibody targeting DNA Polymerase iota. Anti-DNA Polymerase iota Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Accumulates at replication forks after DNA damage.
组织特异性Ubiquitous. Highly expressed in testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DNA Polymerase iota
抗原种属
Human
基因名称
POLI
基因ID
11201
蛋白名称
DNA polymerase iota
Uniprot ID
Q9UNA4
功能
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
化学信息
分子量Theoretical: 83 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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