购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DMPK Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05203

Anti-DMPK Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DMPK。Anti-DMPK Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-DMPK Polyclonal Antibody

Anti-DMPK Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05203

Anti-DMPK Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DMPK。Anti-DMPK Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-DMPK Polyclonal Antibody is a Rabbit antibody targeting DMPK. Anti-DMPK Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Single-passtype IV membrane protein; Cytoplasmic side (By similarity). Nucleusouter membrane; Single-pass type IV membrane protein; Cytoplasmicside (Probable). Mitochondrion outer membrane; Single-pass type IVmembrane protein (Probable). Sarcoplasmic reticulum membrane (Bysimilarity). Cell membrane (By similarity). Cytoplasm, cytosol (Bysimilarity). Note=Localizes to sarcoplasmic reticulum membranes ofcardiomyocytes (By similarity).Isoform 1: Mitochondrion membrane.Isoform 3: Mitochondrion membrane.
组织特异性Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Myotonic dystrophy protein kinase is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis (1). DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction (2,3). DM arises through expansion of CTG repeats in the 3’-UTR of the DMPK gene (4). Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus (5). These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype (6). Other substrates for DMPK include myogenin, L-type calcium channels, and Phospholemman (PLM) (1).
抗原信息
免疫原
KLH conjugated synthetic peptide: human DMPK
抗原种属
Human
基因名称
DMPK
基因ID
1760
蛋白名称
Myotonin-protein kinase
Uniprot ID
Q09013
功能
Non-receptor serine/threonine protein kinase which isnecessary for the maintenance of skeletal muscle structure andfunction. May play a role in myocyte differentiation and survivalby regulating the integrity of the nuclear envelope and theexpression of muscle-specific genes. May also phosphorylatePPP1R12A and inhibit the myosin phosphatase activity to regulatemyosin phosphorylation. Also critical to the modulation of cardiaccontractility and to the maintenance of proper cardiac conductionactivity probably through the regulation of cellular calciumhomeostasis. Phosphorylates PLN, a regulator of calcium pumps andmay regulate sarcoplasmic reticulum calcium uptake in myocytes. Mayalso phosphorylate FXYD1/PLM which is able to induce chloridecurrents. May also play a role in synaptic plasticity.
化学信息
分子量Theoretical: 69 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-DMPK Polyclonal Antibody | purchase Anti-DMPK Polyclonal Antibody | Anti-DMPK Polyclonal Antibody cost | order Anti-DMPK Polyclonal Antibody | Anti-DMPK Polyclonal Antibody molecular weight