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Anti-DLL4 Antibody (6A800)
还可以产品编号 TMAY-00398
Anti-DLL4 Antibody (6A800) 是一种 Mouse 抗体，靶向 DLL4。Anti-DLL4 Antibody (6A800) 可用于 ELISA,ELISA(Cap)。
Anti-DLL4 Antibody (6A800)
Anti-DLL4 Antibody (6A800)
还可以产品编号 TMAY-00398
Anti-DLL4 Antibody (6A800) 是一种 Mouse 抗体，靶向 DLL4。Anti-DLL4 Antibody (6A800) 可用于 ELISA,ELISA(Cap)。
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产品介绍
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抗原信息
| 产品描述 | Anti-DLL4 Antibody (6A800) is a Mouse antibody targeting DLL4. Anti-DLL4 Antibody (6A800) can be used in ELISA,ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6A800 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Cap) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DLL4 / Delta4 extracellular domain (rh DLL4; TMPY-01321; NP_061947.1; Met 1-Pro 524). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| 研究背景 | Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human DLL4 protein (TMPY-01321) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Notch Pathway |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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