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Anti-DGCR8 Antibody (5I166)

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货号 TMAB-05113

Anti-DGCR8 Antibody (5I166) 是一种 Rabbit 抗体，靶向 DGCR8。Anti-DGCR8 Antibody (5I166) 可用于 WB,ICC/IF,IP。

Anti-DGCR8 Antibody (5I166)

Anti-DGCR8 Antibody (5I166)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05113

Anti-DGCR8 Antibody (5I166) 是一种 Rabbit 抗体，靶向 DGCR8。Anti-DGCR8 Antibody (5I166) 可用于 WB,ICC/IF,IP。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-DGCR8 Antibody (5I166) is a Rabbit antibody targeting DGCR8. Anti-DGCR8 Antibody (5I166) can be used in WB,ICC/IF,IP.
Ig Type
IgG
克隆号
5I166
反应种属
Human,Mouse,Rat
应用WBICC/IFIP
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Nucleus; nucleolus. Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies.
组织特异性Ubiquitously expressed.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus.
抗原信息
免疫原
A synthesized peptide: human DGCR8
抗原种属
Human
基因名称
DGCR8
基因ID
54487
蛋白名称
Microprocessor complex subunit DGCR8
Uniprot ID
Q8WYQ5
功能
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.
化学信息
分子量Theoretical: 86 kDa. Actual: 100 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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