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Anti-DGCR8 Antibody (2I601)
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产品编号 TMAH-00343
别名 pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12
Anti-DGCR8 Antibody (2I601) 是一种抗体，靶向 DGCR8。Anti-DGCR8 Antibody (2I601) 可用于 ELISA, WB。
Anti-DGCR8 Antibody (2I601)
Anti-DGCR8 Antibody (2I601)
还可以产品编号 TMAH-00343 别名 pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12
Anti-DGCR8 Antibody (2I601) 是一种抗体，靶向 DGCR8。Anti-DGCR8 Antibody (2I601) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-DGCR8 Antibody (2I601) is an antibody targeting DGCR8. Anti-DGCR8 Antibody (2I601) can be used in ELISA, WB. |
| 别名 | pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12 |
| Ig Type | Rabbit IgG |
| 克隆号 | 2I601 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: K562 whole cell lysate -All lanes: DGCR8 antibody at 2.65μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 87, 33, 83 KDa -Observed band size: 100 KDa |
| 应用 | |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994). |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing. Involved in the silencing of embryonic stem cell self-renewal. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human DGCR8 |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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