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Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody

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货号 TMAB-05066

Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Deformed Epidermal Autoregulatory Factor 1。Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody 可用于 WB。

Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody

Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05066

Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Deformed Epidermal Autoregulatory Factor 1。Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品描述
Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody is a Rabbit antibody targeting Deformed Epidermal Autoregulatory Factor 1. Anti-Deformed Epidermal Autoregulatory Factor 1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Rat,Chicken,Dog,Cow,Horse,Human)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%. Isoform 2: Secreted. Note=Secreted in some cell types. Isoform 3: Secreted. Note=Secreted in some cell types. Isoform 4: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.
组织特异性Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Suppressin, also known as DEAF1 is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Deformed Epidermal Autoregulatory Factor 1
抗原种属
Human
基因名称
DEAF1
基因ID
10522
蛋白名称
Deformed epidermal autoregulatory factor 1 homolog
Uniprot ID
O75398
功能
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.
化学信息
分子量Theoretical: 59 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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